Accumetrics VerifyNow P2Y12 AssayVerifyNow P2Y12 Assay

Thienopyridines such as Plavix (clopidogrel) block the P2Y12 ADP binding site on the platelet. The VerifyNow P2Y12 assay uses ADP and PGE1 as agonists to induce platelet activation and ascertain the level of platelet function impaired by the medication. It also incorporates a second channel containing thrombin receptor agonists to approximate an absolute baseline function so that there is no need to withdraw patients from their medication. Studies show that up to 30% of patients taking Plavix have low levels of platelet inhibition (response) and do not receive the expected antiplatelet effect and may be sub-therapeutic or unnecessarily delayed from surgery. The quantitative assay provides a simple measurement to determine whether or not a patient is responding adequately to their therapy.

Additional Documentation

Instructions for Use (PDF), Interpreting Results (PDF), VerifyNow System (PDF),
Waiting for Clopidogrel (PDF)