Clinical Publications Citing VerifyNow P2Y12 Test:

Author(s)Title and Reference
Ang L, et al.Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel.

J Am Coll Cardiol. 2008 Sep 23;52(13):1052-9.
Angiolillo DJ, et al.Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives.

J Am Coll Cardiol. 2007 Apr 10;49(14):1505-16.
Angiolillo DJ, et al.Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment.

Am J Cardiol. 2008 Feb 15;101(4):440-5.
Angiolillo DJ, et al.A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.

Eur Heart J. 2008 Sep;29(18):2202-11.
Bonello, et al.Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance.

J Am Coll Cardiol. 2008 Apr 8;51(14):1404-11.
Buonamici, et alImpact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis.

J Am Coll Cardiol. 2007 Jun 19;49(24):2312-7.
Chen L, et al.Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting.

J Thorac Cardiovasc Surg. 2004 Sep;128(3):425-31.
Collet JP, et al.Dose effect of clopidogrel reloading in patients already on 75-mg maintenance dose: the Reload with Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term with Dual Antiplatelet Therapy (RELOAD) study.

Circulation. 2008 Sep 16;118(12):1225-33. Epub 2008 Sep 2. Erratum in: Circulation.2008 Oct 14;118(16): e672.
Comment in: Circulation. 2008 Sep 16;118(12):1219-22.
Cuisset T, et al.Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris.

Am J Cardiol. 2008 Jun 15;101(12):1700-3.
Dupont, et alAntiplatelet therapies and the role of antiplatelet resistance in acute coronary syndrome.

Thrombosis Research. 2009;124(1):6-13
Gladding P, et al.The Pharmacogenetics and Pharmacodynamics of Clopidogrel Response: An Analysis From the PRINC (Plavix Response in Coronary Intervention) Trial.

J Am Coll Cardiol Intv. 2008 Dec;1:620-27
Gurbel P, et al.Clopidogrel resistance?

Thromb Res. 2007;120(3):311-21.
Gurbel P, et al.Platelet Function Monitoring in Patients with Coronary Artery Disease.

J Am Coll Cardiol. 2007 Nov 6;50(19):1822-34.
Hobson AR, et al.Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy.

Thromb J. 2008 Feb 29;6:1.
Jakubowski JA, et al.Effect of prasugrel and high dose clopidogrel on platelet function as assessed by point-of-care and optical aggregometry.

J Thromb Haemost 2007; 5 Supplement 2: P-S-346
Jakubowski JA, et al.The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administration.

J Thromb Haemost. 2008 Feb;99(2):409-15.
Jeong YH, et al.The optimal threshold of high post-treatment platelet reactivity could be defined by a point-of-care VerifyNow P2Y12 assay.

Eur Heart J. 2008 Jul 9.
Jeong YH, et al.Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) randomized study.

J Am Coll Cardiol. 2009 Mar 31;53(13):1101-9.
Lee DH, et al.Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience.

Am J Neuroradiol. 2008 Aug;29(7):1389-94.
Lev EI, et al.Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance.

J Am Coll Cardiol. 2006 Jan 3;47(1):27-33.
Lordkipanidzé M, et al.Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients.

Eur Heart J. 2008 Dec;29(23):2877-85
Lordkipanidzé M, et al.Assessment of VerifyNow P2Y12 assay accuracy in evaluating clopidogrel-induced platelet inhibition.

Ther Drug Monit. 2008 Jun;30(3):372-8.
Malinin A, et al.Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel.

Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.
Malinini A, et al.Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12 rapid analyzer: The VERIfy Thrombosis risk ASsessment (VERITAS) study.

Thromb Res. 2007;119(3):277-84.
Marcucci, et alCardiovascular Death and Nonfatal Myocardial Infarction in Acute Coronary Syndrome Patients Receiving Coronary Stenting Are Predicted by Residual Plalelet Reactivity to ADP Detected by a POC Assay. A 12-Month Follow-up

Circulation. 2009 Jan 20;119(2):237-42.
McLean DS, et al.A point of care assay to measure platelet aggregation in patients taking clopidogrel.

Future Medicine. 2006; 2(3): 255-267.
McLean DS, et al.The clinical potential of a point-of-care assay to assess interindividual variability in platelet aggregation among patients taking clopidogrel.

Critical Pathways in Cardiology. 2006; 5(2): 103–113.
Muller-Schunk S, et al.Monitoring of Clopidogrel-Related Platelet Inhibition: Correlation of Nonresponse with Clinical Outcome in Supra-aortic Stenting.

Am J Neuroradiol. 2008 Apr;29(4):786-91
Patti G, et al.Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) study.

J Am Coll Cardiol. 2008 Sep 30;52(14):1128-33.
Prabhakaran S, et al.Prevalence and Risk Factors for Aspirin and Clopidogrel Resistance in Cerebrovascular Stenting.

Am J Neuroradiol. 2008 Feb;29(2):281-5.
Price MJ, et al.Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation.

Eur Heart J. 2008 Apr;29(8):992-1000. Comment in: Eur Heart J. 2008 Apr;29(8):957-8. Eur Heart J. 2008 Jun;29(11):1471; author reply 1471-2.
Price MJ, et al.Onset and offset of platelet Inhibition after high-dose clopidogrel loading and standard daily therapy measured by a point-of-care assay in healthy volunteers.

Am J Cardiol. 2006 Sep 1;98(5):681-4.
Price MJ, et al.Dynamics of platelet functional recovery following a clopidogrel loading dose in healthy volunteers.

Am J Cardiol. 2008 Sep 15;102(6):790-5.
Price MJ.Emerging concepts in the response to antiplatelet therapy.

Cath Lab Digest. 2006; 14(1): 1-7.
Price MJ, et al.Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: Design and rationale of the GRAVITAS trial.

American Heart Journal. 2009;157:818-824
Price MJ, et al.Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention.

Am J Cardiol. 2009 May 15;103(10):1339-43
Saw J, et al.The Effects of Aspirin and Clopidogrel Response on Myonecrosis After Percutaneous Coronary Intervention: A BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) Trial Substudy.

J Am Coll Cardiol Intv. 2008 Dec;1:654-59.
Saw J, et al.The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study.

J Am Coll Cardiol. 2008 Dec 2;52(23):1826-33.
Serebruany V, et al.Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease.

Thromb Haemost. 2008 Jul;100(1):76-82.
Serebruany VL, et al.Variability in platelet responsiveness to clopidogrel among 544 individuals.

J Am Coll Cardiol. 2005 Jan 18;45(2):246-51.
Serebruany VL, et al.Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in diabetic patients: the PLavix Use for Treatment Of Diabetes (PLUTO-Diabetes) trial.

Am Heart J. 2008 Jan;155(1):93.e1-7. Comment in: Am Heart J. 2008 Jun;155(6):e47; author reply e49
Serebruany VL, et al.Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting: the subset from the JUMBO study.

Postgrad Med J. 2006 Jun;82(968):404-10.
Shim CY, et al.The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation.

Int J Cardiol. 2009 May 29;134(3):351-5.
Tourmousoglou CE, et al.Clopidogrel and aspirin in cardiovascular medicine: responders or not - current best available evidence.

Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):312-22.
van Werkum JW, et al.A head-to-head comparison between the VerifyNowP2Y12 assay and light transmittance aggregometry for monitoring the individual platelet response to clopidogrel in patients undergoing elective PCI.

J Thromb Haemost. 2006 Nov;4(11):2516-8.
van Werkum JW, et al.The use of the VerifyNow system to monitor antiplatelet therapy: a review of the current evidence.

Platelets. 2008 Nov;19(7):479-88.
Varenhorst C, et al.Assessment of P2Y(12) inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin.

Am Heart J. 2009 Mar;157(3):562.e1-9.
von Beckerath N, et al.A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite.

Thromb Haemost. 2005 Apr;93(4):789-91.
von Beckerath N, et al.A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75mg of clopidogrel for 30 days.

Eur Heart J. 2008 Feb;29(3):423-4.
von Beckerath N, et al.Correlation of a new point-of-care test with conventional optical aggregometry for the assessment of clopidogrel responsiveness.

J Thromb Haemost. 2006 May;95(5):910-1.
Wang TH, et al.Aspirin and clopidogrel resistance: an emerging clinical entity.

Eur Heart J. 2006 Mar;27(6):647-54.
Wiviott S, et al.Prasugrel compared with high loading-and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention.

Circulation. 2007 Dec 18;116(25):2923-32.
Wiviott S, et al.Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial.

Circulation. 2007 Dec 18;116(25):2923-32.


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